| CITY | STREET ADDRESS | STATE | ZIP | Website |
| Aiken | 2062 Whiskey Rd | SC | 29803 | Aiken |
| ANDERSON | 1405 E GREENVILLE ST | SC | 29621-2049 | Anderson |
| Ballentine | 1330 Dutch Fork Road | SC | 29063-0568 | Ballentine |
| BLUFFTON | 1008 FORDINGISLAND RD | SC | 29910 | Bluffton |
| BOILING SPRINGS | 1888 BOILINGSPRINGS RD | SC | 29316-5124 | Spartanburg |
| CHARLESTON | 59 GEORGE ST | SC | 29401-1422 | Charleston |
| CHARLESTON | 2566 Ashley River Rd - Route 21 | SC | 29414 | 2566 Ashley River |
| CLEMSON | 1300 TIGER BLVD | SC | 29631-1114 | http://www.minuteclinic.com/SC/Greenville-Spartanburg-Anderson/Clemson-Tiger-Blvd.aspx |
| COLUMBIA | 900 ASSEMBLY ST | SC | 29201-3938 | Columbia-Assembly-Street |
| COLUMBIA | 121 CLEMSON RD | SC | 29229-6545 | Columbia-Clemson-Road |
| COLUMBIA | 4310 HARDSCRABBLE RD | SC | 29229-9423 | Columbia-Hardscrabble-Road |
| COLUMBIA | 2373 AUGUSTAHWY | SC | 21359 | Lexington-Augusta-Hwy |
| Conway | 2996 E Highway 501 | SC | 29526 | Conway |
| EASLEY | 5269 CALHOUNMEMORIAL HWY | SC | 29640-3865 | Easley |
| FORT MILL | 1740 HIGHWAY160 W | SC | 29708-8025 | Fort-Mill |
| GREENVILLE | 2210 LAURENSRD | SC | 29607-3224 | Greenville-Laurens-Road |
| GREENVILLE | 3901 PELHAM RD | SC | 29615-5004 | http://www.minuteclinic.com/SC/Greenville-Spartanburg-Anderson/Greenville-Pelham-Ro ad.aspx |
| HILTON HEAD ISLAND | 10 POPE AVE | SC | 29928-4719 | Hilton-Head-Island |
| INDIAN LAND | 7697 CHARLOTTE HWY | SC | 29707-9653 | Indian-Land |
| IRMO | 1008 LAKE MURRAY BLVD | SC | 29063-2821 | Irmo |
| Lancaster | 333 Lancaster Byp E | SC | Lancaster | |
| LEXINGTON | 5608 SUNSET BLVD | SC | 29072-2728 | Lexington-Lake-Drive-North |
| Lexington-S Lake Drive | 1071 S Lake Dr | SC | 29073-3719 | |
| MAULDIN | 224 E BUTLERRD | SC | 29662-2129 | Mauldin |
| MOORE | 5895 REIDVILLE RD | SC | 29369-8409 | Moore |
| MOUNT PLEASANT | 1676 N HIGHWAY 17 | SC | 29464-3310 | Mount-Pleasant |
| MURRELLS INLET | 3710 HIGHWAY17 | SC | 29576-5005 | Murrells-Inlett |
| MYRTLE BEACH | 1303 38TH AVEN | SC | 29577-1315 | Myrtle-Beach |
| NORTH MYRTLE BEACH | 1010 HIGHWAY17 N | SC | 29582-2806 | N-Myrtle-Beach |
| PAWLEYS ISLAND | 10317 OCEAN HWY | SC | 29585-6520 | Pawleys-Island |
| ROCK HILL | 2707 CELANESERD | SC | 29732-9406 | http://www.minuteclinic.com/NC/Charlotte/Rock-Hill.aspx |
| SIMPSONVILLE | 698 FAIRVIEWRD | SC | 29680-6708 | Simpsonville |
| SIMPSONVILLE | 2580 WOODRUFFRD | SC | 29681-5447 | Simpsonville-Woodruff-Road |
| Summerville | 301 N Main St | SC | 29483 | Summerville |
| TAYLORS | 3300 WADE HAMPTON BLVD | SC | 29687-2902 | Taylors |